Biological dressings including human amniotic membrane have been used to cover wounds or skin defects and enhance healing by providing a structural format to the underlying tissue. Human amniotic membrane was first used as wound dressing in 1910 by JS Davis [1]. The amniotic membrane obtained from human placenta possesses most of the characteristics of an ideal skin substitute even after proces...

The fetal membrane surrounds the fetus during pregnancy and is a thin tissue composed of two layers, the chorion and the amnion. While rupture of this membrane normally occurs at term, preterm rupture can result in increased risk of fetal mortality and morbidity, as well as danger of infection in the mother. Although structural changes have been observed in the membrane in such cases, the mecha...

A new in vitro model has been developed for studying migration of human polymorphonuclear leukocytes (PMN) through living native cellular and matrix barriers. Human amnion membrane consists of a single layer of epithelium bound to a continuous basement membrane interfacing an avascular collagenous stroma. Living amnion was placed in plastic chambers with separate compartments on each side of th...

BACKGROUND/AIM Our aim was to evaluate the impact of in vitro cultured amnion cells, injected and/or seeded in different scaffolds, on in vivo fetal membrane repair. MATERIALS AND METHODS Amnion cells, isolated from allogeneic fetal membranes, were cultured on three different scaffolds for 14 to 21 days. In 33 mid-gestational rabbits, fetoscopic access sites were randomly allocated to four cl...

Burns are among the most common traumas in developing countries, which consume large amounts of medical resources. It is important to find an appropriate material for dressing of burn wounds that improves healing and is readily available, easily applicable, and economical and also be protective from infection and desiccation, and facilitate healing. [1] Most burn injuries happen in people with ...

background: hemophilia b is an x-linked hereditary disorder of blood coagulation system which is caused by factor ix (fix) deficiency. factor ix is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. replacement of factor ix with plasma-derived or recombinant factor ix is the conventional treatment for hemophilia b to raise the factor ix level...

OBJECTIVE Ulceration of free flaps in patients with venous insufficiency and/or lymphedema is an uncommon but challenging problem. We hypothesized that dehydrated human amnion/chorion membrane (Epifix) grafts would accelerate healing of these challenging ulcers. METHODS Retrospective analysis of prospectively acquired data identified 8 lower extremity free flaps with ulcerations in the contex...

background: burns are among the most common traumas in developing countries, which consume large amounts of medical resources. it is important to find an appropriate material for dressing of burn wounds that improves healing and is readily available, easily applicable, and economical.   methods: in a single-blind randomized controlled clinical trial from march to october 2006, 211 patients with...

© Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht 2015 R.C. Zhao (ed.), Stem Cells: Basics and Clinical Translation, Translational Medicine Research 1, DOI 10.1007/978-94-017-7273-0_2 Abstract Application of amnion membrane with multiple bioactive biomaterial has over 100 years of history. Amnion membraneand amniotic fluid-derived stem cells mainly in...